Rheological behavior of amniotic membrane-based hydrogel containing Laponite nanoparticles
Paper ID : 1653-ICNS
Authors:
Golara Kafili1, Elnaz Tamjid2, Hassan Niknejad3, Abdolreza Simchi *4
1Institute for Nanoscience and Nanotechnology, Sharif University of Technology
2Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
4Department of Materials Science and Engineering, Sharif University of Technology, Tehran, 14588, Iran
Abstract:
We report the effect of Laponite (LA) nanosilicates on the rheological properties of human amniotic membrane-based nanocomposite hydrogels. Two main influences are illuminated. First, the addition of Laponite to the hydrogel significantly reduces the gelation kinetics (from 7.5 min to 24 min). Second, the storage modulus (Gˈ) is reduced from 420 to 70 Pa with the addition of 10%w LA. These important effects are related to the saturation of LA surface charges in ion-containing medium forming clusters, discontinuity of collagen fibers, and reduced interactions between the particles and the natural polymer matrix.
Keywords:
Injectable hydrogel; Nanocomposite; Storage modulus; Nanosilicate
Status : Abstract Accepted (Poster Presentation)