Metal-Organic Frameworks (MOFs) for enhancement of drug’s bioavailability and pH-controlled release
Paper ID : 1631-ICNS
Mohammad Reza Naimi-Jamal *1, Tahereh Azizi2, Zahra Nadizadeh3
1Department of Chemistry, Iran University of Science and Technology
2Iran University of Science and Technology
3Tehran University
This work reports novel approaches to utilize Nano Metal-Organic Frameworks (NMOFs) including ZIF-8, (Fe)MIL-100, (Fe)MIL-100-Met, {Cu2(1,4-bdc)2(dabco)}n, and {Cu2(1,4-bdc-NH2)2(dabco)}n as promising platforms for drug delivery applications. To this aim, the NMOFs have been synthesized through green processes such as mechanochemical ball-milling and hydrothermal, and loaded with metformin (Met) and ibuprofen (as a model drug). Also, to achieve targeted-drug delivery systems, ZIF-8, (Fe)MIL-100, (Fe)MIL-100-Met MOFs were coated by sodium alginate; a biocompatible pH-responsive polymer. Investigated by FT-IR and UV–vis spectroscopy, XRPD, SEM, TEM, and ICP techniques, the MOFs’ properties, as drug delivery systems were considerably improved; resulted from this coating approach. Hence, these drug delivery systems (DDSs) bring about the continuous release of drugs along with its targeting, as well as increasing drugs' bioavailability.
“NMOFs”, “Drug Delivery Systems”, “Metformin” and “pH-responsive polymer.”
Status : Abstract Accepted (Poster Presentation)