Metal-Organic Frameworks (MOFs) for enhancement of drug’s bioavailability and pH-controlled release
Paper ID : 1631-ICNS
Authors:
Mohammad Reza Naimi-Jamal *1, Tahereh Azizi2, Zahra Nadizadeh3
1Department of Chemistry, Iran University of Science and Technology
2Iran University of Science and Technology
3Tehran University
Abstract:
This work reports novel approaches to utilize Nano Metal-Organic Frameworks (NMOFs) including ZIF-8, (Fe)MIL-100, (Fe)MIL-100-Met, {Cu2(1,4-bdc)2(dabco)}n, and {Cu2(1,4-bdc-NH2)2(dabco)}n as promising platforms for drug delivery applications. To this aim, the NMOFs have been synthesized through green processes such as mechanochemical ball-milling and hydrothermal, and loaded with metformin (Met) and ibuprofen (as a model drug). Also, to achieve targeted-drug delivery systems, ZIF-8, (Fe)MIL-100, (Fe)MIL-100-Met MOFs were coated by sodium alginate; a biocompatible pH-responsive polymer. Investigated by FT-IR and UV–vis spectroscopy, XRPD, SEM, TEM, and ICP techniques, the MOFs’ properties, as drug delivery systems were considerably improved; resulted from this coating approach. Hence, these drug delivery systems (DDSs) bring about the continuous release of drugs along with its targeting, as well as increasing drugs' bioavailability.
Keywords:
“NMOFs”, “Drug Delivery Systems”, “Metformin” and “pH-responsive polymer.”
Status : Abstract Accepted (Poster Presentation)