Cisplatin molecularly imprinted polymer nanoparticles as a drug delivery system
Paper ID : 1623-ICNS
mohammad hassan loghmani *1, ali tavackolimehr2, Seyyedeh Azadeh Hosseini2
1Department of Nanotechnology, University of Guilan, Rasht, Iran
2Department of Nanotechnology, Faculty of Engineering, University of Guilan, Rasht, Iran
In this work, Cisplatin molecularly imprinted polymer (MIP) nanoparticles were created by precipitation polymerization. Morphological properties were determined by scanning electron microscopy and the binding properties of the imprinted nanoparticles were studied by equilibrium binding test. As the result highly uniform imprinted nanoparticles were obtained by Cisplatin /MAA / EGDMA various mole ratios. Among the MIP obtained, the MIPs using Cisplatin / MAA / EGDMA mole ratio of 1:60:60 established nanoparticles with average mean diameter of 30 nm. Results from binding experiments demonstrated that the imprinted nanoparticles with mean diameter of 30 nm had highest specific affinity to Cisplatin (96%) in contrast with other imprinted nanoparticles and non-imprinted particles. Moreover, release experiments proved to be successful in the controlled release of Cisplatin over different time period. MIP nano particles exhibited a much longer period of sustained Cisplatin release than nonimprinted polymer (NIP) nanoparticles due to the interaction of Cisplatin with the Cisplatin -imprinted cavities within the MIP nanoparticles.
Cisplatin, Nanoparticle, Molecular imprinted polymer, Drug delivery
Status : Abstract Accepted (Poster Presentation)