Fabrication of PLGA nanoparticles for encapsulation of Curcumin
Paper ID : 1620-ICNS
Hanie Ahmadi1, Vahid Haddadi-Asl *2
1Deparment of polymer engineering, Amirkabir university of technology, Tehran, Iran
2Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
One of the most important polymeric nano-carriers are nano-carriers that prepared from poly(lactide‐co‐glycolide) (PLGA) because they have broad biomedical applications. In addition to Curcumin anti-inflammatory, antioxidant and antibacterial applications, it has a plant source and can be used as a lipophilic model drug for drug release systems. Therefore, Curcumin was used as model to determine release profile of PLGA-nanoparticle. In present study, PLGA nanoparticles containing Curcumin were electrospryed from different polymeric solutions for optimizing polymer concentration and flow rate. Evaluating the morphology of these particle was done by SEM, TEM analyses. Optimum shaped nanoparticles with an average size of 380 nanometres were observed for neat PLGA nanoparticle (PNP). Also, Curcumin loaded PLGA nanoparticles (CNP) with an average size of 420 were detected. In addition, the In vitro release profile of curcumin was calculated during 100 hour. The results show that electrospray method is effective promising technique for preparing CNPs.
Electrospray; PLGA; Curcumin; Release profile.
Status : Abstract Accepted (Poster Presentation)