The effect of uniformity of nanotube array on Aminopenicillanic acid drug releasing in TiO2 conversion coating
Paper ID : 1606-ICNS
Authors:
seyed Yahya Rahnamaee1, Reza Bagheri *2, Hamed Heidarpour3, Manouchehr Vossoughi4, Mortaza Golizadeh3, Ali Samadikouchaksaraee5
1Institute for Nanoscience and Nanotechnology, Sharif university of technology, Tehran, Iran
2Polymer Materials Research Group (PMRG), Department of Materials Science and Engineering , Sharif University of Technology
3Department of Chemical and Petroleum Engineering, Sharif University of Technology
4Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
5Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences
Abstract:
Fabrication of implants with drug-eluting properties for locally delivering drugs is an attractive way to address some of implant rejecting factors. To improve biomedical properties of titanium implant TiO2 nanotube arrays (TNTs) are considered as biocompatible ceramic coating for localized sustainable drug releasing implants. This study highlights the effect of uniformity of nanotube array on localized drug delivery platforms through different morphologies. Regular TNTs (RTNT) and Irregular TNTs (ITNT) with respectively 80 and 100 nm in diameter and 3 and 5 ┬Ám in length were synthesized on Ti-6Al-4V surfaces by electrochemical anodization and loaded with the water-soluble Aminopenicillanic acid (APA) drug. The different morphologies were proved using FESEM images for as prepared samples. Similar phase structures and optical properties were observed for both samples by using XRD and photoluminescence spectroscopy analysis. The results suggest that TNT with regular arrays has great potential for improving APA drug release. Therefore, the results revealed that the drug release can be easily altered by changing the uniformity and morphology of TNTs.
Keywords:
Titania nanotube arrays, Drug releasing implant, Ti6Al4V, Aminopenicillanic acid, Anodization.
Status : Abstract Accepted (Poster Presentation)