Synthesis of Stimuli-responsive P(NIPAM-co-AAc) Nanogels Loaded with Silibinin for drug delivery applications
Paper ID : 1585-ICNS
Authors:
Meysam Soleymani *1, Reza Davarnejad2, maryam etminanrad3
1Department of Chemical Engineering, Faculty of Engineering, Arak university, Arak, Iran
2Department of Chemical Engineering, School of Engineering, Arak University, Arak
3Arak University
Abstract:
In this study, stimuli-responsive poly(N-isopropylacrylamide-co-acrylic acid) nanoparticles, P(NIPAM-co-AAc), were prepared by dispersion polymerization at the present of Pluronic F127 as a biocompatible surfactant. The morphology, functional groups, and hydrodynamic size distribution of the prepared sample were analyzed by scanning electron micrsocopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS) analyses. The results showed that the prepared sample well-dispersed as individual nearly spherical particles with an average particle size of 102.5 nm. Moreover, the zeta potential of sample was measured to be -12.9 mV, indicating the negative surface charge due to the carboxyl groups of acrylic acid on the surface of sample which can keep the nanoparticles stable at physiological medium. Moreover, the potential of the prepared sample for entrapment and release of silibinin as a hydrophobic drug was studied. The results indicated that the P(NIPAM-co-AA) nanoparticles can be used as a good carrier for poorly water-soluble drugs.
Keywords:
N-isopropylacrylamide; acrylic acid; Pluronic; silibinin; Drug delivery
Status : Abstract Accepted (Poster Presentation)