Letrozole Loaded Biosynthesized Silver Nanoparticles Capped With Cysteine for Breast Cancer Therapy
Paper ID : 1536-ICNS
Mahsa Pourshaban *1, Rahele Safaeijavan2, Elham Moniri3, Homayun AhmadPanahi4
1Department of Biotechnology, Science and research Branch, Islamic Azad University, Tehran,Iran
2Department of Biochemistry and Biophysics, Varamin –Pishva Branch, Islamic Azad University, Varamin, Iran
3Department of Chemistry, Varamin –Pishva Branch, Islamic Azad University, Varamin, Iran
4Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran
In this research we investigated the absorption and release of Letrozole based on modified and biosynthesis silver nanoparticles in optimum conditions with olive leaf extract. Also to enhance the bio-stability, increase the absorption capacity and suitable interaction between nanoparticles and absorption of the drug, the silver nanoparticles were chemically modified with cysteine. The formation of Ag¯ ions to silver nanoparticles monitored by UV-Spectrophotometer. Morphology and distribution of silver nanoparticles confirmed by and Transmission Electron Microscope. Nanoparticles were spherical and their size was estimated below 100 nanometers. The ligand binding on the surface of silver nanoparticles was successfully conducted and confirmed through the devices, infrared spectrometer and elemental analysis test. Factors affecting the absorption of Letrozole on functionalized nanoparticles were optimized. Finally the drug release and delivery from the nano adsorbent was done in simulated stomach and intestines tissues and indicate the suitable release efficiency. All of absorption and release processes in wavelength 240 nm confirmed by UV –Spectrophotometer.
Silver Nanoparticles, Green synthesis, Drug delivery, Letrozole
Status : Abstract Accepted (Poster Presentation)