Preparation and characterization of Chitosan coated magnetic nanoparticles as anticancer drug (Doxorubicin) nanocarrier for drug delivery to tumor cells
Paper ID : 1532-ICNS
Authors:
mahdiye hassani *1, Hamid Akbari javar2, saeed ghanbarzadeh3
1pharmaceutical,medical science of university of Zanjan, Zanjan,Iran
2Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran
3Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran
Abstract:
Magnetite nanoparticles have been successfully synthesized in the presence of chitosan using a coprecipitation method in alkali media. Fe3O4 NPs were synthesised by coprecipitation and surface coating was done by chitosan polymer to avoid agglomeration and we used as a shell around super paramagnetic iron oxide nanoparticles (SPIONs), to introduce an efficient drug carrier for cancer drug delivery and Magnetic Resonance Imagine (MRI). The calibration curve was used to calculate the amount of drug loaded. The drug-loaded content with Fe3O4-chit-Dox NPs was calculated as 75.9% and 9.9%, which are known as loading efficiency and loading capacity values, respectively.
Keywords:
Iron oxide magnetic nanoparticles, Chitosan, Doxorubicin, drug delivery
Status : Abstract Accepted (Poster Presentation)