Influence of Non-Solvent additives on the Structure of Polysulfone Membrane for Removing of Low Density Lipoprotein from Blood plasma
Paper ID : 1491-ICNS
Authors:
Rahim Dehghan1, Jalal Barzin *2
1Faculty of science, Biomaterials department, Iran polymer and petrochemical institute, Tehran, Iran.
2Faculty of science, Biomaterials department, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Abstract:
Todays, polysulfones are a favourite group of polymers which used in blood purification membranes industries. The aim of this study is the influence of water and glycerol as strong and weak non-solvent additives, on the polysulfone (PSf) membrane structure, molecular weight cut-off (MWCO), molecular weight retention onset (MWRO) and mean pore size in order to separation of low density lipoprotein (LDL) from blood plasma (BP). Mean pore size measurements reported that membrane with 36-41 nm mean pore diameter had the best performance based on the MWCO and MWCO/MWRO ratio. Here, we reported the membrane selectivity based on the MWCO/MWRO and attributed this factor to the membrane performance. Blood plasma fractionation demonstrated that optimized membranes had great capability for separation of LDL from blood plasma without significant reduction of other benefit blood plasma substances. Also cardiovascular disease (CVD) risk factors endorsed membrane selectivity. Membrane morphology revealed that membranes with a nodular double-compartment morphology had great capability for separation of LDL together with easy crossing of other plasma substances.
Keywords:
Polysulfone membrane, Low density lipoprotein, Non-solvent, Morphology, MWCO
Status : Abstract Accepted (Poster Presentation)