Study of the Carbon Dots Inhibitory Effect on the Formation of Three-dimensional Tumor Models
Paper ID : 1446-ICNS
Authors:
ESRA ERMIS *1, Zeinab Bagheri2, Hamide Ehtesabi3, shabnam roshani2
1Biology,Life Sciences and Biotechnology at ShahId BehestI Universty , Tahran
2Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C., Velenjak, Tehran, Iran
3Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C., Velenjak, Tehran, Iran)
Abstract:
Carbon dots (CDs) as a new fluorescent material with excellent water solubility, chemical inertness, and facile surface modification are good candidates for bioimaging and diagnosis because of their low toxicity and excellent biocompatibility. Although carbon is not a per se toxic substance, carbon nanomaterials such as CDs can pose a threat to human health, and the potentially harmful effects of CDs on various living systems must be fully determined. So far, cytotoxicity studies on CDs have focused on human cells and have been performed primarily on limited cell lines. This study aimed to investigate the cytotoxic effect of carbon dots on spheroid formation as one of the most commonly used 3D tissue models. The importance of this work is to investigate for the first time the effect of nanoparticles on the formation of tumor spheroid. The results show that as the concentration of CDs increased, the number of spheroids decreased, and their size differed from the control.
Keywords:
“carbon dots”; “spheroid”; “toxicity”; “brain cancer cell”
Status : Abstract Accepted (Poster Presentation)