TiO2@chitosan core-shell nanocomposite immobilized on UiO-66 metal organic frameworks as a strong nanocarrier for the drug delivery of metformin
Paper ID : 1436-ICNS
Mahdiyeh Akbari, Mohammad ali Ghasemzadeh *
Department of chemistry, Islamic azad university, Qom, Iran
Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body some time based on nanoparticles as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. In recent years metal-organic frameworks (MOFs) have been extensively studied for the release of drugs. In this study we have investigated the novel frameworks including TiO2@chitosan@UiO-66 for the delivery of metformin. Moreover, the result of this research showed that 70% of the metformin loaded on the synthesized framework. Drug release was done at PH=7.4 and PH=5 within 2 days, resulting about 50% release of the drug. Finally all of products were characterized by Fourier-transform infrared spectroscopy (FT-IR), Field emission scanning electron microscopy (FE-SEM) and Energy-dispersive X-ray spectroscopy (EDX) analysis.
Metal organic frameworks, nanocarrier, drug delivery, metformin
Status : Abstract Accepted (Poster Presentation)