Application of nanofibers in bone, skeletal muscle and skin tissue engineering
Paper ID : 1434-ICNS
Authors:
Sajad Shariat *1, naeim bakhtiar2
1Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2Young Researchers and Elite Club, Shahreza Branch, Islamic Azad University, Shahreza, Iran
Abstract:
Electrospun nanofibrous matrix has the ability to mimic the role of extracellular matrix (ECM) of natural human tissue at nano-meter scale. The microporous structure and high surface-area-to-volume ratio of nanofibers are favourable for the adhesion, proliferation, and differentiation of cells. In the past decade, three important techniques were used for the fabrication of nanofibers namely as phase separation, self-assembly, and electrospinning. Among them, electrospinning is in the centre of attention due to its advantages in tissue engineering. Nanofibers with high surface area and porosity allow the cells to interact with them and use them as potential scaffolds for the regeneration of damaged tissues. Usually the synthesized nanofibers are in range of 50 - 1000 nm. Various approaches can be used for the fabrication of the three-dimensional scaffolds for the regenerative medicine applications. In the past decade, various nanofibrous systems have been fabricated and their possible applications in tissue engineering were explored. In this study, we focused on three mostly endeavoured applications in bone, skeletal muscle and skin tissue engineering.
Keywords:
Nanofibers, bone tissue, skeletal muscle tissue, skin tissue, biomedical
Status : Abstract Accepted (Poster Presentation)