Polymeric Microparticles with Nano Calcium Peroxide Loading for Controlled Release of Oxygen in Tissue Regeneration
Paper ID : 1411-ICNS
Authors:
Elham Mohseni Vadeghani1, Sajedeh Khorshidi1, Reza Karimi Soflou2, Akbar Karkhaneh *1
1Department of biomedical engineering, Biomedical engineering faculty, Amirkabir university of technology, Tehran, Iran
2Department of Biomedical engineering, Biomedical engineering faculty, Amirkabir university of technology, Tehran, Iran
Abstract:
An important limitation in clinical tissue engineering is insufficient oxygen delivery to the cells that exist in the central regions of a tissue scaffold. Using of oxygen generating scaffolds is one of the approaches to overcome this challenge. In this study, calcium peroxide (CPO) nanoparticles as oxygen generating elements were used to prevent hypoxia in tissue engineered scaffold. CPO nanoparticles were synthesized using a hydrolysis-precipitation method and then loaded in polylactic acid (PLA) microparticles via an emulsion method. The XRD result proved that the CPO nanoparticles were formed and DLS analysis showed that the CPO nanoparticles were 300 nm in diameter. Moreover, the results showed that oxygen release profile of CPO-loaded microparticles was sustained and significantly higher than microparticles with no CPO up to 15 days. The experimental findings indicated that CPO-loaded microparticles can be used as oxygen generating vehicles for engineering of large and irregular tissues with hypoxia condition.
Keywords:
Calcium peroxide; Nanoparticles; Oxygen release; Tissue engineering
Status : Abstract Accepted (Poster Presentation)