Preparation and characterization of oxygen-releasing nanocomposite microspheres
Paper ID : 1402-ICNS
Sara Nejati1, Reza Karimi soflou2, Sajedeh Khorshidi2, Akbar Karkhaneh *3
1Department of Biomedical Engineering, Amirkabir Universiyt of Technology (Tehran Polytechnic), Tehran, Iran
2Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
3Tissue engineering department, Biomedical engineering faculty, Amirkabir university of technology, Tehran, Iran
Despite significant progress in the field of tissue engineering, some continued challenges have restricted the applicability of 3D scaffolds, especially the large ones. One of the major obstacles is oxygen deficiency before the establishment of blood vessels due to the low dissolution and diffusion of oxygen in tissue matrices. Hence, providing a scaffold with an external oxygen supply would be a promising approach. In this study, oxygen-releasing nanocomposite microspheres were prepared by incorporating the nanoparticles of the mixture of hydrogen peroxide (as an oxygen supplier) and polyvinylpyrrolidone into polylactic acid (PLA) using modified double emulsion technique. The effect of the PLA concentration on various characteristics including size of particles and their surface nanopores, encapsulation efficiency of H2O2 and its release behaviour was studied. The results indicated that increasing PLA concentration from 1.5%w/w to 6%w/w led to increasing the particles’ size from 23.41µm to 43.36µm. It also resulted in enhancing both encapsulation efficiency from 9.35% to 59.47% and loading content from 7.36% to 14.49%. It can be strongly suggested that the nanocomposite microspheres prepared in this study can be used for supplying oxygen to where cells and tissues are deprived of necessary oxygen.
Oxygen deficiency, Oxygen-releasing nanocomposite microspheres, Hydrogen peroxide
Status : Abstract Accepted (Poster Presentation)