mSynthesis of ZnS:Mn fluorescent nanoparticles and investigating Effect of its on photodynamic efficiency of Protoporphyrin IX
Paper ID : 1390-ICNS
Authors:
Zahra Mahmoodian *1, Ehsan Sadeghi2, Mostafa Zahedifar2
1Institute of Nanoscience and Nanotechnology, University of Kashan, Kashan, I.R.Iran
2Department of Physics, University of Kashan, Kashan, I.R.Iran
Abstract:
Photodynamic therapy is one of the non-invasive methods of cancer treatment. However, due to the limitation of the depth of light penetration in the body, it is not suitable for the treatment of deep cancers. In this study, we investigated the ZnS:Mn nanoparticle (NPs) synthesis method and its application in photodynamic therapy. The ZnS:Mn NPs were successfully produced through an obvious co-precipitation method. The structure, shape, and morphology of ZnS:Mn NPs were confirmed by XRD, SEM and TEM analysis. The results of the TEM analysis showed that the ZnS:Mn NPs were smaller than 20 nm in size. The prepared NPs were conjugated to protoporphyrin IX (PpIX) sensitizer. The production of singlet Oxygen was investigated using an optical method. In this method, the singlet oxygen production was observed using the changes in the intensity of anthracene emission (singlet oxygen detector) before and after irradiation. The results demonstrated that ZnS:Mn NPs can be used as a light source in photodynamic therapy.
Keywords:
Photodynamic therapy, PpIX, ZnS:Mn
Status : Abstract Accepted (Poster Presentation)