Study of Titanium Oxide Nanotube Array Systems as Thymol Nanoreservoirs for Antibacterial Applications
Paper ID : 1387-ICNS
Fateme nowruzi1, Rana Imani *2, shahab faghihi3
1biomedical engineering Amirkabir university, Tehran
2Biomedical Engineering Department, Amirkabir Univerisity of Technology, Tehran, Iran
3National Institute of Genetic Engineering and Biotechnology
Todays, the need for orthopedic and dental implants has widely increased. Among the metals used for dental and bone implants, titanium and its alloys are remarkable and significant due to their chemical stability, good biocompatibility, high mechanical properties and corrosion resistance. Despite of great advances in developing Titanium-based implants, bacterial infections serve as the major causes of early failure of these implants. Therefore, the implant modification aiming to improve their antibacterial properties seems beneficial. Here, Thymol, as a plant derived antibacterial is introduced in the surface of Ti-based implant with potential of sustained release. Titanium oxide nanotube arrays are constructed on the Ti surfaces by electrochemical anodization is considered as a Thymol nanoreservoirs. Drug loading and releasing profile are investigated. Data shows that this nanoreservoir system supports Thymol release to at least 24 hrs. In summary, the Thymol- functionalized Ti implant has potential for localized antibacterial delivery of dental/orthopaedic applications.
“TiO_2 nanotubes”; “Thymol”; “drug delivery”; “anodize”; “antibacterial”
Status : Abstract Accepted (Poster Presentation)