Electrically Controlled Drug Rerelease from Graphene Oxide Nanoribbon/Polypyrrole Nanocomposite
Paper ID : 1375-ICNS
Nahid Rezvani Jalal1, Tayyebeh Madrakian *2, abbas afkhami3, arash ghoorchian1
1buali sina university
2Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran
3faculty of chemistry, Bu-Ali Sina University, Hamedan, Iran
Controlled drug release provides a means for effective drug dosing while reducing the adverse effects of systemic drug delivery. This work explores an electrically controlled drug delivery nanocomposite composed of graphene nanoribbon (GNR) deposited with a polypyrrole (PPy) scaffold as a conducting polymer. The nanocomposite is loaded with a drug molecule, Leucovorin (LV) as a colorectal cancer drug, and exhibits favorable electrical properties. Electrostatic interaction between cationic PPy with anionic LV increases drug doping. Then release kinetics were investigated at various applied potentials and temperatures. We have shown that drug release from the nanocomposite is controlled by the application of electrically force. No drug passively diffuses from the composite in the absence of stimulation. Kinetics analysis based on Avrami's equation showed that the drug release was controlled and accelerated by increasing temperature and at -0.8 V. The nanostructured polymer film (LV/PPy/GNR) was characterized by several techniques: FESEM, Raman, UV-Vis and EIS spectroscopy. The capacity of drug loading, half-time and kinetic rate constant has been obtained as 51.15 mg/g, 20.64 min and 0.36 min-1, respectively. This approach represents a novel interactive drug delivery system that can show a release profile with a temporal and dosage control.
Graphene nanoribbon, Conducting polymers, Controlled release, Nanocomposite, Electrically stimulate.
Status : Abstract Accepted (Poster Presentation)