Targeted Delivery of Curcumin Anticancer Drug Using a pH-Responsive Chitosan-Based Nanocarrier
Paper ID : 1301-ICNS
Mazaher Ahmadi1, Soheila Akbari Asrari2, Mohammadreza Moradi3, Abbas Afkhami2, Tayyebeh Madrakian *2
1Faculty of Chemistry, Bu-Ali Sina University
2Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517866915, Iran
3Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
The approaches in synthesizing new nanocarriers tend to prepare personalized nanomedicines with regard to abnormal conditions of the patients such as in pathological areas including tumors. It is well known that different cancers show abnormal conditions such as changes in pH, temperature, and redox concentration. Therefore, the concept of stimuli-sensitive drug delivery systems was established toward the development of personalized nanomedicines that are sensitive to the patient’s abnormal conditions. This paper reports on the preparation and characterization of a curcumin loaded nanocarrier. The nanocarrier was synthesized using chitosan as the coating material. The chitosan coating layer was cross-linked by trisodium citrate for the first time to enable pH-responsivity property in the final product. The results showed that the material used for the preparation of the nanocarrier were all biocompatible and caused no significant cytotoxicity against the CT26 colon cancer cell line. The release studies confirmed that the nanocarrier was pH-responsive and the drug release was higher at lower pH values. The MTT assay results also confirmed the pH-responsivity of the nanocarrier as the IC50 values were decreased as the time of incubation was increased.
Drug Delivery Systems, pH-Sensitive Drug Delivery Systems, Chitosan Nanocarriers, Curcumin, Colon Cancer
Status : Abstract Accepted (Poster Presentation)