Investigating the Degradation of MIL-100-Fe in Water and Phosphate Buffer Saline
Paper ID : 1284-ICNS
Authors:
Mahdi Barjasteh *1, Manouchehr Vossoughi2, Mojtaba Bagherzadeh3, Kamran Pooshang Bagheri4
1Institute for Nano-science and Nanotechnology, Sharif University of Technology, Tehran, Iran
2Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
3Department of Chemistry, Sharif University of Technology, Tehran, Iran
4Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Abstract:
In this study, MIL-100-Fe was synthesized as a bio-compatible metal organic framework (MOF) by a simple and green method at room temperature. This structure was characterized by X-ray diffraction (XRD) and its morphology was investigated by filed-emission scanning electron microscope (FESEM). Synthesis at room temperature has the advantage of loading the biological agents, which are mostly temperature sensitive, in MOFs. The degradation of the MIL-100-Fe structure was investigated by releasing the trimesic acid organic linker of MIL-100-Fe in water and phosphate buffer saline (PBS) at pH value of 7.4 under body temperature of 37 C˚. The results of degradation profiles in water and PBS during three days show a 40% and 10% degradation, respectively, confirming the better stability of MIL-100-Fe in water compared to PBS. The low stability in PBS could be attributed to the interaction of phosphate groups with the iron available site in MOF structure. This feature allows the MIL-Fe-100 to be used for controlled release of drugs in physiological conditions.
Keywords:
MIL-100-Fe, degradation, green synthesis
Status : Abstract Accepted (Poster Presentation)