Electrospun Nanofiber Mat Based on PCL/Chitosan to Control Release of Dexamethasone
Paper ID : 1266-ICNS
Aysan Baharian Khoshkhou1, Mina Habibizaddeh *2, Nasser Nikfarjam3, Kobra Rostamizadeh4
1Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran.
2Department of Pharmaceutical Biomaterials, Zanjan University of Medical Sciences, Zanjan, Iran
3Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran
4Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Dexamethasone sodium phosphate (DEXP) loaded PCL/Chitosan nanofiber mats made by electrospinning technique were proposed to be used as efficient wound dressing with controlled drug release. In the first step, PCL nanofibers containing different chitosan content were prepared and morphology of nanofibers was investigated by FE-SEM micrographs. The PCL nanofibers included 20 wt.% of chitosan with bead-free morphology and nanofibers with 70-80 nm in diameter was selected as optimized content for the next steps. In the second steps, PCL/Chitosan nanofibers containing DEXP in different content (0, 0.25, 0.5, 0.7 and 2 wt.% related to total polymer content) were prepared and characterized with DSC, TGA, FT-IR and FE-SEM analysis. The results revealed that the size distribution of nanofibers was broadened and the calculated average size was increased from 70 to 110 nm with increasing of dexamethasone. Also, the obtained melting point from DSC thermograms for PCL did not show any changing with increasing of DEXP. Therefore, one can conclude that the DEXP molecules are willing to interact with chitosan chains in nanofibers. Finally, the investigation of the release profile of DEXP for the nanofibers showed that the drug release was promoted with DEXP content.
Chitosan, Dexamethasone, Electrospinning, PCL, Nanofibers, Drug release, Wound dressing.
Status : Abstract Accepted (Poster Presentation)