A Promising Double Network Hydrogel for Tissue Engineering
Paper ID : 1233-ICNS
Authors:
Zahra Mazaheri Tehrani *1, Ali Pourjavadi2
1Department of Chemistry, Sharif University of Technology, Tehran, Iran
2Department of Chemistry, Sharif University of Technology, Tehran, 11365-9516, Iran
Abstract:
A reinforced double network hydrogel (DN) as a candidate for skin scaffold was prepared. It consisted of O-carboxymethyl chitosan, polyvinyl alcohol, honey and CaCl2 and graphene oxide. The various contents of CaCl2 as 30, 45 and 60 wt. % were investigated. Besides, the GO content was studied as 3, 5 and 10 wt. %. The structure of the DN was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis and differential scanning calorimetry. The mechanical properties were evaluated, too. It showed the DN with 45 wt. % CaCl2 was optimized. Moreover, with increasing in GO content, the mechanical strength was increased. Also, the cytotoxicity was evaluated and indicated that DN with 45% CaCl2 and 5% GO, had the acceptable level of biocompatibility. Moreover, BET, EDX, XRD and SEM images were evaluated. the SEM and BET techniques showed porous structure of the DN nanocomposite. Thus, the DN has potential to be applied in tissue engineering as skin scaffold.
Keywords:
Double network hydrogel, Graphene oxide, O-carboxymethyl chitosan, Poly (vinyl alcohol)
Status : Abstract Accepted (Poster Presentation)