Synthesis of a light-responsive nanogel for a remotely stimulated drug release
Paper ID : 1231-ICNS
Mohadeseh Doroodian, Maryam Bahmanpour, Mina Bagherifard, Ali Pourjavadi *
Department of Chemistry, Sharif University of Technology, Tehran, 11365-9516, Iran
Since the second half of twenties century, laser-assistance methods have influenced greatly on biomedical researches through less invasive ways of treatment along with higher precision to increase efficacy of therapeutic drug. In this study, chitosan as a biodegradable backbone with hydrophilic nature and Poly (NIPAM) as a kind of reversible phase-change material were used to contract in response to light and also to absorb hydrophobic drugs. Gold nanoparticles (GNPs) on the surface of chitosan act as photothermal transducer via their surface energy transfer effect. Thereby, spherical and uniform nanocapsules with high photothermal conversion ability was achieved. Drug release profile could be controlled by changing GNPs concentration, Cs/NIPAM weight ratio, and amount of cross-link agent. The role of Fe3O4 nanoparticles on drug release profiles were also examined during the synthesis of the optimized structure of the magnetic nanogels. Our results demonstrate considerable potential of the present intelligent nano-carrier as photo-controlled delivery system for azithromycin (a model of amphiphilic drug) and doxorubicin (as an anticancer drug).
photo-sensitive; gold nanoparticles; drug delivery; doxorubicin
Status : Abstract Accepted (Poster Presentation)