The Effect of Drying Method and Separation Methodology on the Structure and Particle Size of Iron Oxide Nanoparticles
Paper ID : 1230-ICNS
Authors:
Paria GhaderiNejad *1, Najmeh Najmoddin2, mohamad pezeshki-modaress3, farzam jeddi1
1Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, IRAN
2Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran
3Department of Burn Research Center, Iran University of Medical Sciences, Tehran, IRAN
Abstract:
Iron oxide nanoparticles are considered as one of the most suitable options for use in tissue engineering and drug delivery applications, due to their very small size, good magnetic properties and high biocompatibility. The nano magnetite particles were synthesized by co-precipitation from the solution of mixed Fe (II)/Fe (III) salts in alkaline medium. Freeze-dryer and desiccator were used to investigate the effect of drying method. Also, magnet and centrifuge were used to investigate the effect of separation method on the structure and size of nanoparticles. The x-ray diffraction (XRD) pattern of samples confirmed the formation of iron oxide nanoparticles. Based on field emission scanning electron microscopy (FESEM) images, the size of the obtained nanoparticles is as follows: Magnet and desiccator 38 ± 0.4 nm, centrifuge and desiccator 26 ± 0.32 nm, magnet and freeze-dryer 23 ± 0.28 nm, centrifuge and freeze-dryer 20 ± 0.22 nm, centrifuge and liquid nitrogen tank before freeze-drying 15±0.16nm, with crystallite size 14.62, 12.34, 11.79, 10.46 and 9.53 nm respectively based on XRD results. The nanoparticles that were separated by centrifuge and put into liquid nitrogen before freeze-dryer were found to be the smallest particles with the least crystallite size.
Keywords:
Iron oxide nanoparticle; Magnet; Freeze dryer; Desiccator; Centrifuge
Status : Abstract Accepted (Poster Presentation)