In Vitro Sustained Release Study of chlorogenic acid coated with magnetite nanoparticles- chitosan and magnetite nanoparticles -PEG for Drug Delivery System
Paper ID : 1225-ICNS
Farahnaz Barahuie *
University of Sistan and Baluchestan, Zahedan, Iran
Abstract: Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the co-precipitation of iron salts in ammonia hydroxide followed by coating it with chitosan (CS) and polyethylene glycol (PEG) biopolymers to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs–CS and FNPs–PEG were loaded with chlorogenic acid (CA), an anticancer compound to form new nanocomposites (FCSCA and FPEGCA). Fourier transform infrared spectra and X-ray diffraction patterns confirmed that the FPEGCA and FCSCA nanocomposites were successfully fabricated. The release of chlorogenic acid from the FPEGCA and FCSCA nanocomposites was found to be sustained and in controlled manner. An in vitro bioassay study showed that the synthesized nanoparticles may serve as an alternative drug delivery system for treatment of cancer, with the added possibility of sparing surrounding normal cells and tissue.
Nanocomposite, chitosan, iron oxide nanoparticle, polyethylene glycol, chlorogenic acid
Status : Abstract Accepted (Poster Presentation)