Fabrication, characterization and anticancer studies of a novel magnetite nanoparticle-PEG-protocatechuic acid nanocomposite
Paper ID : 1223-ICNS
Authors:
Farahnaz Barahuie *
University of Sistan and Baluchestan, Zahedan, Iran
Abstract:
Over the past few decades, the applications of nanotechnology in many medical areas have been widely developed, especially in the field of drug delivery. There is a wide range of nanoparticles and nanostructure materials being developed for the delivery of therapeutic compounds. Due to their unique physical properties, superparamagnetic iron oxide nanoparticles are increasingly used in medical applications. They are very useful nanocarriers for delivering anticancer drugs in targeted cancer treatment. Magnetic iron oxide nanoparticles (MNPs) were synthesized by co-precipitation method followed by coating with a biocompatible polymer poly ethylene glycol (PEG) and anticancer agent protocatechuic acid (PA). The resulting nanocomposite was characterized using X-ray diffraction and Fourier transform infrared spectroscopy. Moreover, Cytotoxicity study showed that MNP-PEG-PA nanocomposite inhibits the growth of cancer cell lines and exhibits no toxic effects towards normal fibroblast 3T3 cell. The present findings show that synthesized nanosystem is promising tool for potential anticancer drug delivery.
Keywords:
Nanocomposite, iron oxide nanoparticle, Nano drug delivery, polyethylene glycol, protocatechuic acid
Status : Abstract Accepted (Poster Presentation)