Antibacterial Nanofibers Made by Imidazolium based Poly(ionic liquid)s
Paper ID : 1219-ICNS
Mahnaz Hassanpour *
Polymer Chemistry Institute for Advanced Studies in Basic Sciences (IASBS) Zanjan, Iran.
The structure−antibacterial activity relationship between the small molecular compounds and polymers are still elusive. Herein, imidazolium based on ionic liquid (IL) monomers and their related polymers [Poly(ionic liquids), PILs] were synthesized and characterized. Next, the electrospun nanofibers were obtained and then the potential applicability of IL, PIL and the related nanofibers for antibacterial applications were tested. The effect of chemical structure, including carbon chain length of substitution at the N3 position and charge density of cations (bis-imidazolium) on the antimicrobial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was investigated by determination of their minimum inhibitory concentration (MIC). The antibacterial activities of nanofibers were improved and MICs value was decreased with the increase in the alkyl chain length of imidazolium cations and also with increase with charge density in the structure of ILs. For example, those structures included four carbon (C4) and more than C4 have lower MICs in comparison with structures included two carbons in alkyl chains, e.g. ethyl (C2).
Antibacterial, Ionic liquid, Poly(ionic liquid), Nanofibers, Structure−activity relationship.
Status : Abstract Accepted (Poster Presentation)