Synthesis and Characterization of Self-Healing Nanocomposite Based on Reversible Host-Guest Complexation
Paper ID : 1188-ICNS
Masoumeh Mohamadhoseini *
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS),Zanjan,iran
The use of natural compounds to construct reversible networks is an attractive strategy in design of biomaterials. Alginate is a cytocompatible natural polymer and has been commonly used to prepare hydrogels. Adamantanamine (AD) and β-cyclodextrin (βCD) can form stable host-guest inclusion complexes because of the high association constant K and healing rate. In the first step 1-(p-toluenesulfonyl) imidazole was prepared using the reaction between p-toluenesulfonyl chloride and imidazole. Then, mono-6A-(p-toluenesulfonyl)-6A-deoxy-β-cyclodextrin and subsequently aminated cyclodextrin (βCD-EDA) were synthesized. Next, AD and βCD-EDA were covalently grafted onto the alginate backbone separately. Soft self-healing hydrogels with poor mechanical properties were easily formed by mixing the aqueous solutions of these alginate-based polymers. To improve the mechanical properties, βCD-modified ZnO nanoparticles were added to the hydrogels. The dynamic inclusion complexation of the hydrogel presented the self-healing rapidly under ambient atmosphere. Also, the hydrogels could successfully self‐heal its mechanical properties just within 1-2 min after incision.
Self-healing, Host-guest, Cyclodextrin, Zinc oxide nanoparticles (ZnO NPs)
Status : Abstract Accepted (Poster Presentation)