Hybrid Magneto-Fluorescent Nanoparticles for in Vivo Imaging of Tumors in Animal Models
Paper ID : 1175-ICNS
Authors:
Fatemeh Mohandes *
Department of Materials Science and Engineering, Sharif University of Technology
Abstract:
This investigation introduces novel synthesis and characterization of carbon dot (CD)-coated magnetic nanoparticles as contrast agents for optical and MRI techniques in clinical diagnosis. In situ thermolysis of inorganic complexes and aromatic diamines was utilized to prepare CDs@magnetic core-shell nanoparticles with particle sizes of 10-12 nm. To improve in vivo dispersion and biosafety of the nanoparticles, polymer coating was applied with the aid of polyethers consist of hydrophilic groups. MTT assays show that that about 70-90±5% of SK-OV-3 cells is viable after 72 h of incubation with the nanoparticles. It is shown that the fluorescence intensity of the nanoparticles in the tumor tissue region created by 4T1 cells increases over time and the tumors become clearly visible at 60 min post-injection. Relaxivity measurements of phantoms with different concentrations of the nanoparticles using 3.0 Tesla MRI scanner also determine that the nanoparticles can be used as T2 contrast agent for MRI technique.
Keywords:
Hybrid superparamagnetic nanoparticles, Quantum dots, Luminescence
Status : Abstract Accepted (Poster Presentation)