A Tricolor Fluorescence Nanoprobe for Rapid and Visual Discrimination of Dopamine, Norepinephrine and Levedopa
Paper ID : 1173-ICNS
Authors:
Samira Abbasi-Moayed *1, Mohammad Reza Hormozi Nezhad2
1Chemistry Department, Sharif University of Technology, Tehran, 11155-9516, Iran
2Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran‎
Abstract:
In this study, a fluorescence sensor array have been proposed for rapid identification and discrimination of catecholamine neurotransmitters. For this purpose a tricolor fluorescence probe has been constructed by integrating three sensor elements including blue carbon dots (bCDs), green CdTe quantum dots (gQDs) and red CdTe quantum dots (rQDs) into a single well. This single well sensor array exhibit ternary fluorescence emissions at respectively, 450, 520 and 630 nm under a single wavelength excitation (365 nm). After the addition of target analyte, the three fluorescence emission bands of the probe changed differentially, giving rise to fingerprint patterns for each analyte. The unique colorful response patterns were achieved with a single fluorimetric test and were identifiable by naked eye. Pattern recognition techniques including hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were employed for data analysis and discrimination of catecholamine neurotransmitters. Altogether, the developed sensor array can be considered as a rapid and visual tool for diagnostic and therapeutic applications in the near future.
Keywords:
Tricolor fluorescence nanoprobe”, “Fluorescence Sensor array”, “Naked-eye discrimination”, “Catecholamine neurotransmitters
Status : Abstract Accepted (Oral Presentation)