Surface modification of Fe3O4 nanoparticles with polyethylene glycol (PEG): in-situ and post synthesis methods
Paper ID : 1166-ICNS
Mahshid Jafarpour Noshari *1, Seyedeh Aida Razavi2, Najmeh Najmoddin2, Fatemeh Najaran2
1Biomedical engineering, Islamic Azad University, Science and Research Branch, Tehran
2Biomedical engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran
Magnetite nanoparticles (MNPs) have attracted much interest in biomedical applications, such as drug delivery, tissue repair, cell and tissue targeting and MRI imaging. MNPs with narrow size distribution without and with polyethylene glycol (PEG) were synthesized by co-precipitation technique. MNPs coated with PEG were prepared by in-situ and post synthesis methods. The purity of the bare Fe3O4 was studied by X-ray powder diffraction (XRD). Field emission scanning electronic microscopy (FE-SEM) was conducted to evaluate the morphology of the samples. The results showed that the coated nanoparticles were homogenous and spherical, and the morphology of the Fe3O4 nanoparticles didn't considerably change when coated by PEG. Furthermore, the size of the bare Fe3O4 nanoparticles, PEG-Fe3O4-insitu and PEG-Fe3O4-post were approximately 10 nm, 9 nm and 12 nm, respectively. Fourier transform infrared (FT-IR) results analysis indicated the existence of the PEG (i.e. PEG) on the surface of MNPs in both in-situ and post synthesis methods.
Fe3O4, Poly ethylene glycol, Co-precipitation method, In-situ synthesis, Post synthesis
Status : Abstract Accepted (Poster Presentation)