Designing of a novel non-enzymatic sensing platform based on bimetallic Ni-Co-MOFs on a graphitic screen-printed electrode for measuring glucose in human blood serum sample
Paper ID : 1116-ICNS
Authors:
Milad Ezzati1, Hadi Hosseini2, Saeed Shahrokhian *3
1Department of Chemistry, Sharif University of Technology
2Department of Chemistry,Sharif University of Technology
3Department of Chemistry, Sharif University of Technology, tehran, Iran
Abstract:
In this study, for the first time, we reported a fast and facile three-step in-situ strategy for direct controllable growth of the bimetallic Ni-Co-MOFs thin films on the GCE, through the rapid conversion of Ni-Co-LDH nanosheets on ERGO/GCE, to crystalline structures of MOFs. The as-prepared Ni-Co-MOFs were used to construct a non-enzymatic sensing platform for determining the glucose in alkaline solutions. The designed electrode demonstrated two wide linear dynamic range of 0.001 – 1.78 mM and 1.78 -5.03 mM with high sensitivity of 1766 µA mM-1 cm-2 and 1407 µA mM-1 cm-2, respectively, good repeatability and reproducibility, high selectivity against interference species and good poisoning resistance against chloride ions together with a low detection limit. The application of the proposed sensor for the determination of glucose in the human blood serum samples without any sample preparation was investigated and results showed excellent recoveries, which confirmed that the fabricated sensor can act as a reliable and sensitive platform for biological and clinical samples analysis. Finally, in order to develop our procedure from laboratory to market, the same three-step strategy was applied to graphite screen-printed electrode (GSPE) and results showed that the as-synthesized electrode via this fast, facile, inexpensive and reliable method is capable to use as a glucose sensing platform in practical applications.
Keywords:
Direct Growth; Electrodeposition; Bimetallic Ni-Co-MOFs; Amperometric Detection, Non-enzymatic glucose sensor; Graphitic screen-printed electrode
Status : Abstract Accepted (Poster Presentation)