Preparation of β-Cyclodextrin-Citric Acid-Zinc Peroxide composite and Investigation of its Antioxidant Activity
Paper ID : 1087-ICNS
Mahtab Pirouzmand1, parya salahshour sani *2
1University of Tabriz
2university of Tabriz
H2O2 is one of reactive oxygen species (ROS) and its overproduction causes oxidative stress and inflammation events. To minimize the negative effects of ROS, aerobic organisms evolved numerous antioxidant defences, including catalases, superoxide dismutase. Catalase protects the body against H2O2 damage with converts H2O2 to H2O and O2. The natural enzyme is not stable under harsh environmental conditions and its preparation is expensive and time-consuming. Cyclodextrins are widely used in pharmacology as drug delivery and release systems by molecular encapsulation. The aim of the present study was to evaluate the H2O2 scavenging activity of the ZnO2/β-CD as a biocompatible composite. Zinc peroxide was prepared via sonochemical approach. To synthesize a green composite, β-cyclodextrin was modified by citric acid and reacted with ZnO2 under ultrasonic irradiation. The prepared samples were characterized using XRD, SEM, and FTIR analytical techniques. The results of the catalytic assay showed that the ZnO2/βCD-CA composite displayed stronger capability to decompose H2O2 than ZnO2.
H2O2 Scavenger, Cyclod2xtrin, Citric Acid, zinc-peroxide
Status : Abstract Accepted (Poster Presentation)