Electroactive Hydrogels Based on Amine-Functionalized Reduced Graphene Oxide for Cardiac Tissue Engineering Applications
Paper ID : 1076-ICNS
Ali Mousavi *1, Shohreh Mashayekhan1, Nafiseh Baheiraei2, Ali Pourjavadi3
1Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, 11365-8639, Iran
2Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Chemistry, Sharif University of Technology, Tehran, 11365-9516, Iran
Myocardial infarction (MI), also known as heart attack, can lead to irreversible loss of cardiomyocytes, scar formation in the infarcted site, arrhythmias and subsequently heart failure. Using electrically conductive nanomaterials is a very novel and promising approach in cardiac tissue engineering to regenerate damaged heart. In this research, an injectable hydrogel derived from oxidized alginate (OA) and amine-functionalized reduced graphene oxide (Amine-rGO) was synthesized using calcium ions as crosslinking agents in order to develop an electrically conductive constructs for improving the cardiac cell function. The FTIR spectra, elemental analysis and topographical structure of the synthesized nanomaterials were characterized. The effect of OA and calcium concentration on gelation time of the fabricated hydrogels was investigated to obtain the optimum concentration of crosslinker for proper usage in clinical applications. Finally the effect of Amine-rGO nanosheets on electrical conductivity of the constructs was evaluated. These electrically conductive hydrogels can be further applied for cardiac tissue engineering.
Reduced graphene oxide; Oxidized alginate; Electroactive; Hydrogel; Cardiac tissue engineering
Status : Abstract Accepted (Poster Presentation)