The mechanical properties of PET/PCL blend nanofibrous conduit with potential application in vascular tissue engineering
Paper ID : 1054-ICNS
maryam rahmatinejad1, maryam Yousfzadeh *2, Atefeh Solouk3
1Textile Engineering Department, Amirkabir University of Technology,Tehran, Iran
2Textile Engineering Departmanet, Amirkabir University of Technology (polytechnic), Tehran, Iran
3Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran
In recent years, the mortality rate caused by cardiovascular diseases has increased dramatically around the world. Tissue engineering is considered as a novel and efficient approach to substituent of engineered tissues for defective body tissues. For this purpose, fabrication of scaffold that resembles physical and mechanical properties of natural body vessels, and culturing appropriate cells on it is required. Due to fibrous structure of vascular wall, nanofibrous scaffold produced by electrospinning could be a proper choice for vascular tissue engineering. One of the main properties of artificial vessels is its mechanical properties consistency with native one to be able to mimic its natural characteristics. To do this, in present study two biocompatible polymers, polyethylene terephthalate (PET) and polycaprolactone (PCL) with different blend ratio were electrospun into tubular nanofibrous structure with 6 mm diameter. In order to study the morphological features of electrospun scaffolds the scanning electron microscope was used to evaluate the uniformity and diameter of the nanofibrous scaffolds and the mechanical properties as tensile strength and elastic recovery were investigated.
“PET/PCL nanofibers; vascular graft; mechanical properties; Electrospinning”
Status : Abstract Accepted (Poster Presentation)