Effect of pH on Physiochemical Properties of Chitosan Based Polyelectrolyte Nanocarriers
Paper ID : 1052-ICNS
Marjan Motiei *1, Fatemeh Abutalebi2, Zohre Mirahmadi Zare2, Kianoush Dormiani2, Mohammad Hossein Nasr-Esfahani2, Vladimír Sedlařík1
1Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, 76001 Zlín, Czech Republic
2Department of Molecular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
: Interpolyelectrolyte complexation between oppositely charged polymers has emerged as a straightforward and a low-cost alternative to common covalent-based strategy for design of polyelectrolyte nanosystems. Duo to pH-sensitive characteristics of these nanocarriers, the present work has focused specifically on the effect of pH on their physicochemical properties. Therefore, the objective of this work is to develop two types of nanocarriers under acidic and alkaline pH conditions using different biocompatible polymers including chitosan, dextran sulfate and polyethyleneimine. The chitosan based core was prepared by ionic gelation technique in the presence of tripolyphosphate, then polyethyleneimine shell was self-assembled onto the core by negatively charged dextran sulfate. Physicochemical characteristics of the nanocarriers were elucidated by DLS, SEM, FTIR and DSC. The acidic nanocarriers showed higher positive surface charge and narrower particle size distribution than alkaline ones which was confirmed by SEM micrographs, too. Therefore, these results open promising aspects in controlling a simple factor, pH, as an effective and safe parameter to improve the physiochemical characteristics of polyelectrolyte nanocarriers in drug delivery systems.
Polyelectrolyte nanocarriers, Chitosan, Polyethyleneimine, Dextran sulfate, pH
Status : Abstract Accepted (Poster Presentation)