Toward graphene based antibiotics: effect of flake size and bacteria morphology
Paper ID : 1050-ICNS
Authors:
Naimeh Naseri *1, Kinza Huma1, Fahimeh Najafi1, Ali Maghsoumi1, Leila Azimi2, Abdollah Karimi2
1Sharif University of Technology
2Shahid Beheshti University of Medical Science
Abstract:
Today, a predominantly frightening issue in the world health is the growth and prevalence of antibiotic-resistant bacteria, significantly rises the death rates and treatment cost. Besides, an alternative approach to treat and mitigate the infections caused by resistant bacteria is nanomaterials. In this paper, we presented the effect of modified GO sheets on two bacteria S. aureus and P. aeruginosa. We prepared different GO flake sizes from 72 μm2 to 0.004 μm2 in average area. Size analysis was done by AFM while MIC tests and counting bacteria colony over time also performed. Moreover, bacteria/GO interaction has been studied by FESEM. According to our results, the best bacteriostatic result against S. aureus obtained for GO with medium size of 0.063 μm2. When the area decreased to 0.018 μm2 antibacterial property was shown for P. aeruginosa. These results indicated that the GO nanosheets could be used as a promising new material for antibacterial activity while its performance is dependent on shape of bacteria as well as size of the flakes.
Keywords:
Graphene sheets; Size variation; Antibacterial properties; Bacteria shape
Status : Abstract Accepted (Poster Presentation)