The focus of Dr. Angelo Homayoun All’s research is on nervous system injury, repair and regeneration. His laboratory has pioneered the monitoring and quantitative analysis of multi-channel somatosensory and motor-evoked potentials in order to assess the electrical integrity of the nervous system at various stages, both pre- and post-injury. His translational research projects involve hypothermia treatment as well as stem cell replacement therapy derived from human embryonic stem cells, human iPS cells, and direct conversion by trans-differentiation of human adult cells. These stem cells are also modified to induce overexpression of neurotrophic factors in order to modulate the lesion microenvironment and stimulate endogenous regenerative responses post-injury.

A part of Dr All’s laboratory is also investigating the application of upconversion nanoparticles in conjunction with near infrared illumination systems for the neuromodulation applications both in vitro and in vivo. The goal is to develop a semi-invasive tool for stimulating or inhibiting, with spatio-temporal precision, neuropathways situated deep in the nervous system (the spinal cord, motor cortex, vagus nerve, etc) selectively. In addition, his laboratory is studying the adult central nervous system’s capabilities of adaptive changes enabling reorganisation and plasticity in spared neuropathways following neuro-trauma. In his projects, Dr All has also integrated different imaging techniques to monitor anatomical changes in contused spinal cord architectures at various time points enabling him to identify spared fibres (anatomically intact but non-functional neuropathways post-injury) and tracking the extent of secondary injury to determine the therapeutic benefits of the various treatment strategies.